Hakusensha announced the classic shojo manga series Hanazakari no Kimitachi e, better known as Hana-Kimi, will finally inspire an anime adaptation, and Crunchyroll confirmed it will be the streaming source for it outside of Japan. The official site and a trailer are live now. However, there is no release window yet, so we don't know when it will air.
While some details aren't certain, many things have been confirmed. After being inspired by an athlete named Izumi Sano, Mizuki Ashiya becomes determined to attend the same school as him. However, only men can attend Osaka High School, so she has to disguise herself as one to attend. Not only does Mizuki get close to Izumi, he ends up learning her secret and helping her hide it. Another major character is Shuichi Nakatsu, who rounds out the love triangle by being a classmate and friend who ends up falling for her without learning her secret.
Years ago, Viz Media handled the US release of the Hana-Kimi manga. While single volumes aren't available, the company did start releasing 3-in-1 omnibus editions back in 2012. The series ended back in 2004.
The Hana-Kimi anime is in development, and the manga is available worldwide.